I recently added the below images and caption to the Trombone History Timeline (16th century). It’s very similar to another painting from c. 1525 (see Timeline). You can see it in the context of 80 other angel trombonist images here: Angel Trombonists throughout History. To compare the way the instrument was held with other historical examples, see here.
1501-25—Portugal: Assumption of the Virgin (Assunção da Virgem), a painting attributed to Cristovão de Utreque, includes an angel playing trombone (see detail and full image below; public domain) (Museu Municipal Leonel Trindade).